Cnr1^tm1Map
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1Map
• Name: cannabinoid receptor 1; targeted mutation 1, Marc Parmentier
• MGI ID: MGI:1857736
• Synonyms: CB1 KO, CB1-KO, CB1r^-, Cnr1-, Cnr1^tm1Par
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1Map page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52188
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced a genomic fragment containing sequences encoding the first 233 codons of the gene. Northern blot analysis demonstrated the absence of transcripts from this gene in brain and testis of homozygous mice and binding assays confirmed the absence of active protein. (J:52188)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:52188 Ledent C, et al., Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 1999 Jan 15;283(5400):401-4
• All: 93 reference(s)