Foxc2^tm1Miu
Targeted Allele Detail

Summary

• Symbol: Foxc2^tm1Miu
• Name: forkhead box C2; targeted mutation 1, Naoyuki Miura
• MGI ID: MGI:1857740
• Synonyms: Mfh1-, MFH-1-
• Gene: Foxc2 Location: Chr8:121842910-121845634 bp, + strand Genetic Position: Chr8, 70.33 cM
• Alliance: Foxc2^tm1Miu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55316
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the entire coding region of the gene. RT-PCR analysis on RNA derived from E11.5 homozygous embryos confirmed that no detectable transcript was produced from this allele. (J:55316)

Expression

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	33 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc2 Mutation: 15 strains or lines available

References

• Original: J:55316 Iida K, et al., Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development. 1997 Nov;124(22):4627-38
• All: 15 reference(s)