Pax1^tm2Neu
Targeted Allele Detail

Summary

• Symbol: Pax1^tm2Neu
• Name: paired box 1; targeted mutation 2, Neuherberg
• MGI ID: MGI:1857741
• Synonyms: Pax1^lacZ
• Gene: Pax1 Location: Chr2:147203850-147216972 bp, + strand Genetic Position: Chr2, 72.63 cM
• Alliance: Pax1^tm2Neu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55575
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Mice lacking a functional gene were generated by homologous recombination, where a beta galcactosidase gene was introduced within the paired-box encoding exon, resulting in a premature termination of the gene product. (J:55575)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax1 Mutation: 28 strains or lines available

References

• Original: J:55575 Furumoto TA, et al., Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev Biol. 1999 Jun 1;210(1):15-29
• All: 1 reference(s)