Gata2^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Sho
• Name: GATA binding protein 2; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:1857743
• Synonyms: GATA-2-
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20316
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1 kb of sequence containing exon 2. RT-PCR analysis did not detect transcripts in differentiating embryoid bodies derived from homozygous ES cell lines. (J:20316)

Expression

In Mice Carrying this Mutation:	56 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 30 strains or lines available

References

• Original: J:20316 Tsai FY, et al., An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994 Sep 15;371(6494):221-6
• All: 27 reference(s)