Nr3c1^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1Gsc
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:1857745
• Synonyms: GR-, GR^hypo
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27441
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 2. This allele is a hypomorphic allele; an mRNA containing an ORF encoding an amino-terminal truncated protein with intact DNA and ligand-binding domains is generated. (J:27441)

Expression

In Mice Carrying this Mutation:	60 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 35 strains or lines available

References

• Original: J:27441 Cole TJ, et al., Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
• All: 30 reference(s)