En1^tm2Alj
Targeted Allele Detail

Summary

• Symbol: En1^tm2Alj
• Name: engrailed 1; targeted mutation 2, Alexandra L Joyner
• MGI ID: MGI:1857749
• Synonyms: En1^lki, En-1^Lki, En^lacZ
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm2Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27767
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: LacZ sequences were inserted downstream of the En1 promoter. The sequences corresponding to the first 111 amino acids of the reading frame are also deleted. (J:27767)

Disease models

Expression

In Mice Carrying this Mutation:	150 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 34 strains or lines available

References

• Original: J:27767 Hanks M, et al., Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science. 1995 Aug 4;269(5224):679-82
• All: 27 reference(s)