Adam17^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1Imx
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Immunex
• MGI ID: MGI:1857753
• Synonyms: ADAM17^deltaZn, ADAM17^Zndelta, TACE-, tace^deltaZn
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1Imx page

Adam17^tm1Imx/Adam17^tm1Imx embryos develop internal hemorrhage

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin cassette replaced a 1.2kb fragment of the gene, which encodes the zinc-binding domain. (J:38527)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	28 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 64 strains or lines available

References

• Original: J:38527 Black RA, et al., A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997 Feb 20;385(6618):729-33
• All: 42 reference(s)