T^Wis
Spontaneous Allele Detail

Summary

• Symbol: T^Wis
• Name: brachyury, T-box transcription factor T; brachyury Wisconsin
• MGI ID: MGI:1857760
• Synonyms: T1^Wis
• Gene: T Location: Chr17:8653255-8661328 bp, + strand Genetic Position: Chr17, 4.92 cM
• Alliance: T^Wis page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Restriction mapping showed that this allele comprises a 5.5 kb early transposon-like insertion element. RT-PCR based analysis shows that at least 8 different mutant transcripts are produced from the T^Wis allele. These transcripts bypass the mutated exon 7 splice donor site and no wild-type T transcripts are produced. (J:21263, J:107619)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	108 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any T Mutation: 59 strains or lines available

References

• Original: J:9032 Shedlovsky A, et al., Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc Natl Acad Sci U S A. 1988 Jan;85(1):180-4
• All: 13 reference(s)