Ikbkb^tm1Trk
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm1Trk
• Name: inhibitor of kappaB kinase beta; targeted mutation 1, Tularik Inc
• MGI ID: MGI:1857761
• Synonyms: IKK-beta^-
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm1Trk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55680
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette disrupted exon 2 of the gene, which encodes the ATP binding site of the kinase domain. (J:55680)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 56 strains or lines available

References

• Original: J:55680 Tanaka M, et al., Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity. 1999 Apr;10(4):421-9
• All: 1 reference(s)