Adam2^tm1Dgm
Targeted Allele Detail

Summary

• Symbol: Adam2^tm1Dgm
• Name: a disintegrin and metallopeptidase domain 2; targeted mutation 1, Diana G Myles
• MGI ID: MGI:1857764
• Synonyms: fertilin beta^-
• Gene: Adam2 Location: Chr14:66264778-66315182 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Adam2^tm1Dgm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50040
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 14, encoding the predicted disintegrin domain active site. Western blot analysis did not detect the encoded protein in spermatogenic cells and sperm derived from homozygous mice. (J:50040)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam2 Mutation: 42 strains or lines available

References

• Original: J:50040 Cho C, et al., Fertilization defects in sperm from mice lacking fertilin beta. Science. 1998 Sep 18;281(5384):1857-9
• All: 9 reference(s)