Ggt1^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Ggt1^tm1Zuk
• Name: gamma-glutamyltransferase 1; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:1857766
• Synonyms: GGT^-, GGT^m1, GGT^tm1mwl
• Gene: Ggt1 Location: Chr10:75397438-75422034 bp, + strand Genetic Position: Chr10, 38.55 cM
• Alliance: Ggt1^tm1Zuk page

Gross and histologic analysis of wild-type and Ggt1^tm1Zuk/Ggt1^tm1Zuk mice.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34309
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An hprt expression cassette replaced 3kb of 5' sequence, including exons I, 1 and 2, and intervening intronic sequences. (J:34309)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggt1 Mutation: 52 strains or lines available

References

• Original: J:34309 Lieberman MW, et al., Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7923-6
• All: 11 reference(s)