Ggt1^enu1
Chemically induced Allele Detail

Summary

• Symbol: Ggt1^enu1
• Name: gamma-glutamyltransferase 1; enu1
• MGI ID: MGI:1857767
• Synonyms: GGT^enu1
• Gene: Ggt1 Location: Chr10:75397438-75422034 bp, + strand Genetic Position: Chr10, 38.55 cM
• Alliance: Ggt1^enu1 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion at nucleotide 237 altered codon 26 encoding leucine to a termination codon. The level of mRNA is reduced 3-fold in kidney of homozygous mice. Protein is not detectable by Western blot in kidneys of homozygous mice. (J:53697)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggt1 Mutation: 52 strains or lines available

References

• Original: J:55222 Harding CO, et al., Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility. J Biol Chem. 1997 May 9;272(19):12560-7
• All: 5 reference(s)