Gsr^a1Neu
Chemically induced Allele Detail

Summary

• Symbol: Gsr^a1Neu
• Name: glutathione reductase; glutathione reductase 1, Neuherberg
• MGI ID: MGI:1857772
• Synonyms: GR 180, Gr1^a1Neu, Gsr^null
• Gene: Gsr Location: Chr8:34143266-34188190 bp, + strand Genetic Position: Chr8, 20.69 cM
• Alliance: Gsr^a1Neu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (other) (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation is a small deletion that removes nucleotides 10840 through 23627 of the gene and functionally deletes exons 2 through 5. In addition, the deletion produces a frame shift in exon 6 and introduces a stop codon in exon 7 that prevents translation of the remainder of the protein. (J:103511)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

8 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Gsr^a1Neu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsr Mutation: 51 strains or lines available

Notes

Induced by isopropyl methanesulphonate (iPMS)

References

• Original: J:54306 Pretsch W, Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia. Genet Res. 1999 Feb;73(1):1-5
• All: 11 reference(s)