Adcy1^tm1Drs
Targeted Allele Detail

Summary

• Symbol: Adcy1^tm1Drs
• Name: adenylate cyclase 1; targeted mutation 1, Daniel R Storm
• MGI ID: MGI:1857775
• Synonyms: AC1-, I-AC^-
• Gene: Adcy1 Location: Chr11:7013489-7128506 bp, + strand Genetic Position: Chr11, 4.72 cM, cytoband A2
• Alliance: Adcy1^tm1Drs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22287
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection casssette replaced a genomic fragment including part of exon 1. Northern blot analysis demonstrated that the transcript was not detectable in RNA from homozygous mice. (J:22287)

Expression

In Mice Carrying this Mutation:

12 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adcy1 Mutation: 73 strains or lines available

References

• Original: J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
• All: 57 reference(s)