Notch2^tm1Yha
Targeted Allele Detail

Summary

• Symbol: Notch2^tm1Yha
• Name: notch 2; targeted mutation 1, Yoshio Hamaha
• MGI ID: MGI:1857783
• Synonyms: N2^LacZ, Notch2^m
• Gene: Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
• Alliance: Notch2^tm1Yha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55841
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ-neomycin resistance cassette replaced the exons encoding the second through the sixth ankyrin repeats. This allele expresses a beta galactosidase fusion protein. (J:55841)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch2 Mutation: 99 strains or lines available

Notes

In aggregation chimeras with wild-type tetraploid embryos, mutant embryos develop normally until E12.5 but die before E13.5. Chimeric placentas show restored maternal blood sinus formation. (J:120082).

References

• Original: J:55841 Hamada Y, et al., Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development. 1999 Aug;126(15):3415-24
• All: 9 reference(s)