Morc1^Tg(Tyr)1Az
Transgenic Allele Detail

Summary

• Symbol: Morc1^Tg(Tyr)1Az
• Name: microrchidia 1; transgene insertion 1, Andrew R Zinn
• MGI ID: MGI:1857787
• Synonyms: microrchidia, morc, Morc^TgN(Tyr)1Az, Tg(Tyr)1Az
• Gene: Morc1 Location: Chr16:48251600-48451263 bp, + strand Genetic Position: Chr16, 30.75 cM
• Alliance: Morc1^Tg(Tyr)1Az page

Transgene origin

• Strain of Origin: FVB/NHsd

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The random insertion of a transgene into the Morc gene also resulted in the deletion of a ~13 kb genomic fragment containing exons 2-4. The transgene contains a tyrosinase gene under the control of a polymerase (RNA) II (DNA directed) polypeptide A (Polr2a) promoter. RT-PCR analysis on RNA derived from testis of homozygous mice confirmed that no wild-type transcript was present; however an aberrant transcript containing transgene sequences fused to exon 5 and downstream sequences was expressed from this allele. (J:56287)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Morc1 Mutation: 82 strains or lines available

References

• Original: J:51211 Watson ML, et al., Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14361-6
• All: 5 reference(s)