Dlx5^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx5^tm1Jlr
• Name: distal-less homeobox 5; targeted mutation 1, John L R Rubenstein
• MGI ID: MGI:1857789
• Synonyms: Dlx5^-, Dlx5^tm1Ucsf
• Gene: Dlx5 Location: Chr6:6877801-6882068 bp, - strand Genetic Position: Chr6, 2.83 cM
• Alliance: Dlx5^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56559
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 2.2kb of sequence including exons 1 and 2. The mutant allele is predicted to express a truncated protein that lacks the N-terminus, which includes 43 amino acids of the homeodomain. (J:56559)

Expression

In Mice Carrying this Mutation:	59 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	56 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx5 Mutation: 25 strains or lines available

References

• Original: J:56559 Depew MJ, et al., Dlx5 regulates regional development of the branchial arches and sensory capsules. Development. 1999 Sep;126(17):3831-46
• All: 10 reference(s)