Shh^tm1Chg
Targeted Allele Detail

Summary

• Symbol: Shh^tm1Chg
• Name: sonic hedgehog; targeted mutation 1, Chin Chiang
• MGI ID: MGI:1857796
• Synonyms: Shh-, Shh^null
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm1Chg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35802
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK neomycin cassette replaced exon 2 and portions of the flanking intronic sequences in the Shh gene. (J:35802)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	810 assay results
In Structures Affected by this Mutation:	49 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:35802 Chiang C, et al., Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996 Oct 3;383(6599):407-13
• All: 171 reference(s)