Zeb1^tm2Yhi
Targeted Allele Detail

Summary

• Symbol: Zeb1^tm2Yhi
• Name: zinc finger E-box binding homeobox 1; targeted mutation 2, Yujiro Higashi
• MGI ID: MGI:1857799
• Synonyms: deltaEF1^-, deltaEF1^null(lacZ), Tcf8^-, Zeb1^tm2Yhi, Zfhx1a^-
• Gene: Zeb1 Location: Chr18:5591860-5775467 bp, + strand Genetic Position: Chr18, 4.42 cM
• Alliance: Zeb1^tm2Yhi page

Inner ear abnormality in Zeb1^tm2Yhi/Zeb1^tm2Yhi and Zeb1^tm2Yhi/Zeb1^Tw mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45575
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette including termination signals replaced exon 1. The targeted allele encodes a fusion protein that lacks the DNA-binding and homeodomains functionally essential to the endogenous protein. Northern blot analysis showed an absence of normal transcript in homozygous mutant embryos. The expression pattern of beta-galactosidase largely resembled that of the endogenous gene, with the noted exception of expression in the notochord. (J:45575)

Expression

In Mice Carrying this Mutation:	362 assay results
In Structures Affected by this Mutation:	40 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Zeb1^tm2Yhi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zeb1 Mutation: 65 strains or lines available

References

• Original: J:45575 Takagi T, et al., DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development. 1998 Jan;125(1):21-31
• All: 27 reference(s)