Oas1b^Flv-r
Spontaneous Allele Detail

Summary

• Symbol: Oas1b^Flv-r
• Name: 2'-5' oligoadenylate synthetase 1B; flavivirus resistance
• MGI ID: MGI:1857800
• Synonyms: Flv^r
• Gene: Oas1b Location: Chr5:120950700-120962228 bp, + strand Genetic Position: Chr5, 60.64 cM, cytoband F
• Alliance: Oas1b^Flv-r page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This allele confers resistance to flavivirus infection. Susceptible mouse strains produce a protein lacking 30% of the C-terminal region due a nucleotide substitution. The T-to-C transition in resistant strains results in the change of a premature stop codon to an arginine codon at position 253 (p.*253R). (J:77001)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Oas1b Mutation: 15 strains or lines available

Notes

The majority of mouse strains carry the susceptibility allele. Only the Det, BSVR, BRVR, CASA/RK, CAST/Ei, and PRI carry the resistance allele. The MOLD/Rk strain carried the allele for minor resistance.

Genbank ID for this allele: AF481734

References

• Original: J:15009 Sabin AB, Nature of inherited resistance to viruses affecting the nervous system. Proc Natl Acad Sci U S A. 1952 Jun;38(6):540-46
• All: 14 reference(s)