Oas1b^Flv-mr
Spontaneous Allele Detail

Summary

• Symbol: Oas1b^Flv-mr
• Name: 2'-5' oligoadenylate synthetase 1B; minor flavivirus resistance
• MGI ID: MGI:1857802
• Synonyms: Flv^mr
• Gene: Oas1b Location: Chr5:120950700-120962228 bp, + strand Genetic Position: Chr5, 60.64 cM, cytoband F
• Alliance: Oas1b^Flv-mr page

Mutation origin

• Strain of Origin: MOLD/RkJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This minor resistance allele differs from other resistance strains by 14 amino acid substitutions (F26L, S45F, G63C, T65A, S83Y, C103Y, F110C, H118Q, P176L, S183L, I184T, T322A, G347A, and M350T). (J:77001)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oas1b Mutation: 15 strains or lines available

Notes

The majority of mouse strains carry the susceptibility allele. Only the Det, BSVR, BRVR, CASA/RK, CAST/Ei, and PRI carry the resistance allele. The MOLD/Rk strain carries the allele for minor resistance.

References

• Original: J:3674 Sangster MY, et al., Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv). J Virol. 1993 Jan;67(1):340-7
• All: 4 reference(s)