Acox1^tm1Jkr
Targeted Allele Detail

Summary

• Symbol: Acox1^tm1Jkr
• Name: acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy
• MGI ID: MGI:1857811
• Synonyms: ACOX-, Acox1-, AOX-
• Gene: Acox1 Location: Chr11:116062714-116089605 bp, - strand Genetic Position: Chr11, 80.96 cM
• Alliance: Acox1^tm1Jkr page

Hepatocellular alterations in liver of Acox1^tm1Jkr/Acox1^tm1Jkr mice

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35794
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.3kb SstI-BamHI segment containing exons 8 and 9 was replaced with a neomycin selection cassette. The 3.8-kb transcript is undetectable in RNA derived from the livers of homozygous mice by Northern blot. Western blots and enzymatic assays confirmed the absence of functional protein in homozygous mice. (J:35794)

Disease models

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Acox1^tm1Jkr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acox1 Mutation: 42 strains or lines available

References

• Original: J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
• All: 19 reference(s)