Lat^tm1Les
Targeted Allele Detail

Summary

• Symbol: Lat^tm1Les
• Name: linker for activation of T cells; targeted mutation 1, Lawrence E Samelson
• MGI ID: MGI:1857812
• Synonyms: LAT^-, LAT^KO
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm1Les page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced ~3.9 kb of sequence containing exons 1 - 8 of the gene, which encode amino acids 1 - 169 of the protein. No protein for the targeted gene was detected on immunoblots of lysates of thymocytes from homozygous mutant mice. (J:54059)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 10 strains or lines available

References

• Original: J:54059 Zhang W, et al., Essential role of LAT in T cell development. Immunity. 1999 Mar;10(3):323-32
• All: 42 reference(s)