Edar^Tg(OVE1B)Ove
Transgenic Allele Detail

Summary

• Symbol: Edar^Tg(OVE1B)Ove
• Name: ectodysplasin-A receptor; transgene insertion OVE1B, Paul Overbeek
• MGI ID: MGI:1857813
• Synonyms: Edar^{TgN(OVE1B)Ove}, OVE 1B
• Gene: Edar Location: Chr10:58436611-58511476 bp, - strand Genetic Position: Chr10, 29.37 cM, cytoband B3
• Alliance: Edar^Tg(OVE1B)Ove page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic
• Mutations: Deletion, Insertion, Inversion
• Mutation details: A transgene containing a hybrid DNA construct, which includes the regulatory sequences of the mouse alpha-crystallin gene and the early region of SV40, inserted into the gene. A founder mouse from one microinjection event produced offspring carrying two different integration sites. The subsequent lines were called Edar^{TgN(OVE1A)Ove} and Edar^{TgN(OVE1B)Ove}. In both cases, integration was accompanied by a genomic deletion and an intrachromosomal inversion. The deletions were found to be overlapping. This allele is defined by a noncomplementation test with Edar^dl, and contains a 600 kb deletion. (J:10318, J:50575, J:56496)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edar Mutation: 30 strains or lines available

Notes

Similar phenotypes have also been described in mice for the Tabby allelic series at the Eda locus.

References

• Original: J:10318 Shawlot W, et al., Insertional inactivation of the downless gene in a family of transgenic mice. Mol Biol Med. 1989 Aug;6(4):299-307
• All: 5 reference(s)