Ntrk2^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Bbd
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1857814
• Synonyms: gp145^trkB, trkB-, trkB^null, trkB^TK(-)
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56847
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Gene disruption by insertion of a PGK-neomycin cassette into exon K2, which encodes subdomains III - V of the tyrosine kinase domain. (J:56847)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:56847 Klein R, et al., Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 1993 Oct 8;75(1):113-22
• All: 62 reference(s)