Rxrb^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Rxrb^tm1Ipc
• Name: retinoid X receptor beta; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:1857822
• Synonyms: Rarbeta^-, RXRbeta^-, Xbeta
• Gene: Rxrb Location: Chr17:34250786-34257373 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Rxrb^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30560
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequences encoding the DNA-binding domain in exons 3 and 4 were replaced by a neomycin cassette. RT-PCR analysis on total RNA derived from several tissues of homozygous mice revealed that transcripts corresponding to exon 2 as well as exons 5-9 were present at low levels in homozygous mice. The authors do not rule out the possiblility that some mutant protein could be expressed in homozygotes. (J:30560)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxrb Mutation: 27 strains or lines available

References

• Original: J:30560 Kastner P, et al., Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 1996 Jan 1;10(1):80-92
• All: 13 reference(s)