Dlx1^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx1^tm1Jlr
• Name: distal-less homeobox 1; targeted mutation 1, John L Rubenstein
• MGI ID: MGI:1857826
• Synonyms: Dlx-1-, Dlx-1-D2.8/neo
• Gene: Dlx1 Location: Chr2:71358457-71364325 bp, + strand Genetic Position: Chr2, 42.61 cM
• Alliance: Dlx1^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40427
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin resistance cassette replaced exons 2 and 3 of the Dlx1 gene. (J:40427)

Expression

In Mice Carrying this Mutation:	60 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx1 Mutation: 21 strains or lines available

References

• Original: J:40427 Qiu M, et al., Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15;185(2):165-84
• All: 25 reference(s)