Dlx2^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx2^tm1Jlr
• Name: distal-less homeobox 2; targeted mutation 1, John L R Rubenstein
• MGI ID: MGI:1857828
• Synonyms: Dlx-2-, Dlx-2-D5/neo
• Gene: Dlx2 Location: Chr2:71373752-71377095 bp, - strand Genetic Position: Chr2, 42.65 cM
• Alliance: Dlx2^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29443
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced part of exon 1 and all of exons 2 and 3. Northern analysis of poly(A)+ RNA using a probe that corresponds to exon 3 did not detect transcript in homozygous mutant whole E14.5 embryo. In situ RNA hybridization did not detect gene expression in the gut of E14.5 homozygous mutant embryos. (J:29443)

Expression

In Mice Carrying this Mutation:	79 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx2 Mutation: 25 strains or lines available

References

• Original: J:29443 Qiu M, et al., Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 1995 Oct 15;9(20):2523-38
• All: 20 reference(s)