Mgat3^tm1Pst
Targeted Allele Detail

Summary

• Symbol: Mgat3^tm1Pst
• Name: mannoside acetylglucosaminyltransferase 3; targeted mutation 1, Pamela Stanley
• MGI ID: MGI:1857829
• Synonyms: Mgat3^neo, Mgat3^T37
• Gene: Mgat3 Location: Chr15:80057922-80099720 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E
• Alliance: Mgat3^tm1Pst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48441
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the coding region of the gene, disrupting it. Northern blots of brain and kidney RNA from homozygous mutant mice showed a lack of endogenous transcript for the targeted gene. (J:48441)

Expression

In Mice Carrying this Mutation:	7 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mgat3^tm1Pst

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgat3 Mutation: 32 strains or lines available

References

• Original: J:48441 Bhaumik M, et al., Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. Cancer Res. 1998 Jul 1;58(13):2881-7
• All: 7 reference(s)