Pax7^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Pax7^tm1Pgr
• Name: paired box 7; targeted mutation 1, Peter Gruss
• MGI ID: MGI:1857831
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32018
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the first exon of the paired box. This targeting strategy was expected to abolish the DNA binding activity of the paired domain. (J:32018)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 38 strains or lines available

References

• Original: J:32018 Mansouri A, et al., Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development. 1996 Mar;122(3):831-8
• All: 17 reference(s)