Npr3^lgj-2J
Spontaneous Allele Detail

Summary

• Symbol: Npr3^lgj-2J
• Name: natriuretic peptide receptor 3; longjohn 2 Jackson
• MGI ID: MGI:1857835
• Synonyms: lgj-2J
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^lgj-2J page

Wild-type and Npr3^lgj-2J/Npr3^lgj-2J, Npr3^lgj/Npr3^lgj and Npr3^stri/Npr3^stri mutants showing kyphosis.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A C-to-T transition mutation at coding nucleotide 283 (c.283C>T) introduces a premature stop codon at glutamine codon 95 (p.Q95*). (J:57460)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 49 strains or lines available

Notes

Genbank: AF131863

References

• Original: J:57460 Jaubert J, et al., Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3). Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10278-83
• All: 2 reference(s)