Npr3^stri
Chemically induced Allele Detail

Summary

• Symbol: Npr3^stri
• Name: natriuretic peptide receptor 3; strigosus
• MGI ID: MGI:1857836
• Synonyms: stri
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^stri page

Forepaw skeletal staining images.

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: Outbred

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A C-to-A transversion mutation at coding nucleotide 502 (c.502C>A) leads to a histidine to asparagine substitution (p.H168N) in a highly conserved region of the protein. Experiments in cultured cells indicate that the mutant protein is retained in the endoplasmic reticulum. (J:57460, J:243806)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 50 strains or lines available

Notes

Genbank: AF131864

References

• Original: J:57460 Jaubert J, et al., Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3). Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10278-83
• All: 2 reference(s)