Hoxa1^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm1Mrc
• Name: homeobox A1; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:1857840
• Synonyms: Hox-1.6^-, Hoxa1^-
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1776
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into sequences encoding the homeodomain. Note that this allele disrupts expression of only one of two alternatively spliced transcripts. (J:1776)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	145 assay results
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:1776 Chisaka O, et al., Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6 [see comments]. Nature. 1992 Feb 6;355(6360):516-20
• All: 4 reference(s)