Fgf5^tm1Mrt
Targeted Allele Detail

Summary

• Symbol: Fgf5^tm1Mrt
• Name: fibroblast growth factor 5; targeted mutation 1, Gail R Martin
• MGI ID: MGI:1857847
• Synonyms: FGF-5-, Fgf^neo
• Gene: Fgf5 Location: Chr5:98402108-98424892 bp, + strand Genetic Position: Chr5, 47.77 cM, cytoband E1-F
• Alliance: Fgf5^tm1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20551
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin cassette into exon 1. (J:20551)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf5 Mutation: 15 strains or lines available

Notes

This mutation produces abnormally long hair, the phenotype being very closely similar to that of Fgf5^go homozygotes (angora, J:20551).

References

• Original: J:20551 Hebert JM, et al., FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell. 1994 Sep 23;78(6):1017-25
• All: 4 reference(s)