Rarb^tm1Mma
Targeted Allele Detail

Summary

• Symbol: Rarb^tm1Mma
• Name: retinoic acid receptor, beta; targeted mutation 1, Manuel Mark
• MGI ID: MGI:1857851
• Synonyms: RARbeta-
• Gene: Rarb Location: Chr14:5650540-6038924 bp, + strand Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
• Alliance: Rarb^tm1Mma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43344
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exon 9 and a 5' region of exon 10, both of which encode a portion of the functionally essential ligand-binding domain common to all isoforms. Western blot analysis demonstrated an absence of functional protein in homozygous mutant embryos. RNAse protection assays of mRNA derived from homozygous mutant embryos showed that only truncated transcripts were present. (J:43344)

Expression

In Mice Carrying this Mutation:	155 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarb Mutation: 40 strains or lines available

References

• Original: J:43344 Ghyselinck NB, et al., Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997 Jun;41(3):425-47
• All: 15 reference(s)