Unc5c^{rcmTg(Ucp)1.23Kz}
Transgenic Allele Detail

Summary

• Symbol: Unc5c^{rcmTg(Ucp)1.23Kz}
• Name: unc-5 netrin receptor C; rostral cerebellar malformation (Tg(Ucp)1.23Kz)
• MGI ID: MGI:1857852
• Synonyms: rcm^tg, TgN(Ucp)1.23Kz, Unc5c^{rcmTgN(Ucp)1.23Kz}, Unc5h3^-
• Gene: Unc5c Location: Chr3:141171360-141540685 bp, + strand Genetic Position: Chr3, 65.57 cM
• Alliance: Unc5c^{rcmTg(Ucp)1.23Kz} page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intergenic deletion
• Mutation details: The random insertion of a transgene into the Unc5c gene resulted in a ~8.5 kb genomic deletion at the insertion site. The deleted region includes a putative 110 bp exon. Northern blot analysis on adult cerebellar mRNA derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:40243)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5c Mutation: 61 strains or lines available

References

• Original: J:28673 Boyer BB, et al., The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell Biol. 1991 Aug;11(8):4147-56
• All: 22 reference(s)