Nrp1^tm1Hfu
Targeted Allele Detail

Summary

• Symbol: Nrp1^tm1Hfu
• Name: neuropilin 1; targeted mutation 1, Hajime Fujisawa
• MGI ID: MGI:1857853
• Synonyms: NP1^-
• Gene: Nrp1 Location: Chr8:129085085-129229844 bp, + strand Genetic Position: Chr8, 75.78 cM, cytoband E
• Alliance: Nrp1^tm1Hfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44328
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaces sequences encoding the a1 domain of the protein. The mutant allele was expected to encode only the signal peptide and the most N-terminal 7 amino acid residues of the protein. Immunohistochemical analysis of homozygous mutant embryos demonstrated the lack of intact protein. (J:44328)

Expression

In Mice Carrying this Mutation:	46 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nrp1 Mutation: 84 strains or lines available

References

• Original: J:44328 Kitsukawa T, et al., Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 1997 Nov;19(5):995-1005
• All: 31 reference(s)