Hoxd^tm3Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm3Ddu
• Name: homeobox D cluster; targeted mutation 3, Denis Duboule
• MGI ID: MGI:1857854
• Synonyms: Hoxd12^tm1Ddu, HoxD^RXI, L2
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47900
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: A neomycin resistance cassette flanked by loxP sites replaced the regulatory element, RXI, located in the intergenic region between Hoxd12 and Hoxd13. This selection cassette was excised by breeding mice carrying this mutation with a Cre deleter strain. (J:47900)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:47900 Herault Y, et al., Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development. 1998 May;125(9):1669-77
• All: 3 reference(s)