Hoxb1^tm2Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb1^tm2Mrc
• Name: homeobox B1; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:1857857
• Synonyms: hoxb-1^neoB
• Gene: Hoxb1 Location: Chr11:96256578-96259082 bp, + strand Genetic Position: Chr11, 59.86 cM
• Alliance: Hoxb1^tm2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36235
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of a 371 bp BglII fragment of exon 2 with a neomycin cassette and an insertion of a 12 bp linker into exon 1. No HOXB1 immunoreactivity was detectable in homozygous embryos by whole-mount immunohistochemistry. (J:36235)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb1 Mutation: 24 strains or lines available

References

• Original: J:36235 Goddard JM, et al., Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development. 1996 Oct;122(10):3217-28
• All: 1 reference(s)