Hoxb1^tm3Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb1^tm3Mrc
• Name: homeobox B1; targeted mutation 3, Mario R Capecchi
• MGI ID: MGI:1857859
• Synonyms: Hoxb1^BloxP
• Gene: Hoxb1 Location: Chr11:96256578-96259082 bp, + strand Genetic Position: Chr11, 59.86 cM
• Alliance: Hoxb1^tm3Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of a 371 bp BglII fragment of exon 2 with a loxP-flanked neomycin cassette and an insertion of a 12 bp linker into exon 1. The neomycin cassette was removed via Cre-mediated recombination in the final allele. (J:41540)

Expression

In Mice Carrying this Mutation:	105 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb1 Mutation: 24 strains or lines available

References

• Original: J:41540 Rossel M, et al., Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development. 1999 Nov;126(22):5027-40
• All: 2 reference(s)