Parp1^tm1Zqw
Targeted Allele Detail

Summary

• Symbol: Parp1^tm1Zqw
• Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Zhao-Qi Wang
• MGI ID: MGI:1857862
• Synonyms: ADPRT^-, Adprt1^tm1Wag, ARTD1^-, PARP-, PARP-1-, PARS^-, PKO
• Gene: Parp1 Location: Chr1:180396456-180428564 bp, + strand Genetic Position: Chr1, 84.44 cM, cytoband H5
• Alliance: Parp1^tm1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23942
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice. (J:23942)

Expression

In Mice Carrying this Mutation:	14 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Parp1^tm1Zqw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Parp1 Mutation: 66 strains or lines available

References

• Original: J:23942 Wang ZQ, et al., Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 1995 Mar 1;9(5):509-20
• All: 126 reference(s)