Foxc2^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Foxc2^tm1Blh
• Name: forkhead box C2; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:1857865
• Synonyms: Foxc2-, mfh1^tm1
• Gene: Foxc2 Location: Chr8:121842910-121845634 bp, + strand Genetic Position: Chr8, 70.33 cM
• Alliance: Foxc2^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39636
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomyin selection cassette replaced all of the coding sequences of the gene. In situ hybridization experiments on sections of homozygous embryos confirmed that no detectable transcript was expressed from this allele. (J:39636)

Expression

In Mice Carrying this Mutation:	148 assay results
In Structures Affected by this Mutation:	30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc2 Mutation: 15 strains or lines available

References

• Original: J:39636 Winnier GE, et al., The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 1997 Apr 1;11(7):926-40
• All: 16 reference(s)