Apaf1^{Gt(IRESBetageo)XIX18Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Apaf1^{Gt(IRESBetageo)XIX18Pgr}
• Name: apoptotic peptidase activating factor 1; gene trap XIX18, Peter Gruss
• MGI ID: MGI:1857868
• Synonyms: Apaf1-, Apaf1^tm1Pgr
• Gene: Apaf1 Location: Chr10:90825173-90918632 bp, - strand Genetic Position: Chr10, 45.47 cM, cytoband C3-D1
• Alliance: Apaf1^{Gt(IRESBetageo)XIX18Pgr} page

Mutation origin

• Mutant Cell Line: XIX18
• Germline Transmission: Earliest citation of germline transmission: J:49840
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pSABetageo Vector Type: gene trap
• Mutation details: Insertion of a gene trap vector at the 3' end of the gene downstream of the position corresponding to amino acid 1018. (J:49840)

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apaf1 Mutation: 78 strains or lines available

References

• Original: J:40076 Chowdhury K, et al., Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 1997 Apr 15;25(8):1531-6
• All: 19 reference(s)