Hoxd13^tm1Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd13^tm1Ddu
• Name: homeobox D13; targeted mutation 1, Denis Duboule
• MGI ID: MGI:1857871
• Synonyms: Hoxd-13^-, Hoxd-13^St
• Gene: Hoxd13 Location: Chr2:74498654-74501943 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd13^tm1Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15507
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the sequences encoding the 11th amino acid of the homeobox domain. (J:15507)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd13 Mutation: 24 strains or lines available

References

• Original: J:15507 Dolle P, et al., Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell. 1993 Nov 5;75(3):431-41
• All: 17 reference(s)