Sod1^tm1Leb
Targeted Allele Detail

Summary

• Symbol: Sod1^tm1Leb
• Name: superoxide dismutase 1, soluble; targeted mutation 1, Russell M Lebovitz
• MGI ID: MGI:1857873
• Synonyms: Cu,Zn-SOD^-, CuZnSOD-, SOD1^-, SOD1^m1BCM
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^tm1Leb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64299
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exons 1 and 2 with a PGK-hprt expression cassette. Protein was not detected in brain of homozygous mutant mice. (J:64299)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 39 strains or lines available

References

• Original: J:64299 Matzuk MM, et al., Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology. 1998 Sep;139(9):4008-11
• All: 80 reference(s)