Msr1^tm1Csk
Targeted Allele Detail

Summary

• Symbol: Msr1^tm1Csk
• Name: macrophage scavenger receptor 1; targeted mutation 1, Chugai Pharmaceutical Co, Ltd
• MGI ID: MGI:1857874
• Synonyms: MSR-, Msr1-KO, Msr1^tm1Kod, Scara1^_, Scvr^tm1, SR-, Sra^-, SR-A-, SR-AI/II KO, SRAKO, SRKO
• Gene: Msr1 Location: Chr8:40034726-40095714 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Msr1^tm1Csk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39079
• Parent Cell Line: A3-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. (J:39079)

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Msr1 Mutation: 12 strains or lines available

References

• Original: J:39079 Suzuki H, et al., A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 1997 Mar 20;386(6622):292-6
• All: 139 reference(s)