Drd2^tm1Low
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1Low
• Name: dopamine receptor D2; targeted mutation 1, Malcolm J Low
• MGI ID: MGI:1857875
• Synonyms: D2-, D2 KO, D2KO, D2R^-, Drd2-
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1Low page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41858
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 7 and part of exon 8 was replaced by a neomycin resistance cassette. (J:41858)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:41858 Kelly MA, et al., Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 1997 Jul;19(1):103-13
• All: 104 reference(s)