Atp2b2^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Atp2b2^tm1Ges
• Name: ATPase, Ca++ transporting, plasma membrane 2; targeted mutation 1, Gary E Shull
• MGI ID: MGI:1857876
• Synonyms: Pmca2 -
• Gene: Atp2b2 Location: Chr6:113720803-114019574 bp, - strand Genetic Position: Chr6, 52.85 cM
• Alliance: Atp2b2^tm1Ges page

Atp2b2^tm1Ges/Atp2b2^tm1Ges mice exhibit an unsteady gait and difficulty in maintaining balance

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48863
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 19, which encodes transmembrane domains essential for transport activity. Northern blot analysis demonstrated that no detectable transcript was produced from this allele in brain of homozygous mice. (J:48863)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp2b2 Mutation: 66 strains or lines available

References

• Original: J:48863 Kozel PJ, et al., Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem. 1998 Jul 24;273(30):18693-6
• All: 15 reference(s)