Notch1^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Notch1^tm1Grid
• Name: notch 1; targeted mutation 1, Tom Gridley
• MGI ID: MGI:1857877
• Synonyms: Notch1-, Notch1ⁱⁿ³²
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17509
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into an exon encoding EGF repeat 32, disrupting the reading frame of the protein. (J:17509)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:17509 Swiatek PJ, et al., Notch1 is essential for postimplantation development in mice. Genes Dev. 1994 Mar 15;8(6):707-19
• All: 26 reference(s)