Pitx2^tm1Kki
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm1Kki
• Name: paired-like homeodomain transcription factor 2; targeted mutation 1, Kunio Kitamura
• MGI ID: MGI:1857880
• Synonyms: Pitx2-
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm1Kki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55455
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 4 of this gene was replaced with a STOP-IRES-LacZneo cassette via homologous recombination. Homozygous mutant embryos were identified by Southern blot analysis. (J:55455)

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 39 strains or lines available

References

• Original: J:55455 Kitamura K, et al., Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development. 1999 Dec;126(24):5749-58
• All: 3 reference(s)